Some potential post-doctoral projects include:
Investigating novel approaches to prevent ischemia reperfusion injury during transplantation to improve transplant outcomes. This project will focus on mechanistic studies to better understand the role of galectin-3 in modulating immune and inflammatory responses in the context of vascularized composite tissue transplantation (i.e. limb or face) in rodent and swine models, and will involve investigating novel therapeutic interventions targeting galectin-3.
Studying the mechanistic basis for induction of stable B-cell tolerance to transplantation antigens to facilitate development of clinically relevant approaches to overcome chronic antibody-mediated rejection in the clinic. This project is based on our findings in the pre-clinical swine model demonstrating induction of stable B-cell tolerance following donor hematopoietic cell infusion using a novel CD3 immunotoxin-based induction protocol. Mechanistic studies will be pursued in mice.