Job Description
Current studies in our research program are focused on understanding the mechanisms for the early activation of fetal hepatic glucose production and development of hepatic insulin resistance, specifically the role of reduced glucose versus oxygen supply to the fetus, both key features of placental insufficiency and resulting fetal growth restriction (FGR). This is important in understanding why FGR offspring have increased susceptibility to diabetes across their lifespan. We also have projects investigating the effects of maternal high fat diet and obesity on offspring metabolism, specifically the early development of hepatocellular injury, including fibrosis and steatosis, and immune cell reprogramming. New projects are also investigating the effects of metformin exposure on the developing fetal liver and the postnatal consequences.