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|09/23/2022||Christene A. Huang, PhD||The Huang laboratory studies transplantation immunology with a focus on developing clinically relevant protocols for the establishment of transplantation tolerance||Some potential post-doctoral projects include: Investigating novel approaches to prevent ischemia reperfusion injury during transplantation to improve transplant outcomes. This project will focus on mechanistic studies to better understand the role of galectin-3 in modulating immune and inflammatory responses in the context of vascularized composite tissue transplantation (i.e. limb or face) in rodent and swine models, and will involve investigating novel therapeutic interventions targeting galectin-3. Studying the mechanistic basis for induction of stable B-cell tolerance to transplantation antigens to facilitate development of clinically relevant approaches to overcome chronic antibody-mediated rejection in the clinic. This project is based on our findings in the pre-clinical swine model demonstrating induction of stable B-cell tolerance following donor hematopoietic cell infusion using a novel CD3 immunotoxin-based induction protocol. Mechanistic studies will be pursued in mice.||Christene.Huang@CUAnschutz.edu|
|09/02/2022||Susan L. Johnson, PhD||This position reports directly to the Director of The Children’s Eating Laboratory, Susan L. Johnson, PhD in the Section of Nutrition, and will be responsible for a Vitamix Foundation funded intervention project.||The project will involve implementing complex research plans, the development of methods of research, testing and data collection, analysis and evaluation, and writing reports containing descriptive, analytical and evaluative content. The duties will require the exercise of independent discretion and judgment in carrying out research activities, including supervision of research personnel, within the predetermined research scope and methodology. You will be required to participate in literature searches, visit scheduling and data collection, data coding and analysis, manuscript development, development of conference presentations and reports for funding agencies. You will also be required to participate in lab and equipment maintenance, ordering of supplies as needed, use available technology effectively to facilitate the success of the project, liaise with other departments, outside collaborators, and others to ensure success of project.||Please contact Katherine.Barrett@cuanschutz.edu or Susan.Johnson@cuanschutz.edu for more information|
|08/29/2022||Jessica Kendrick, MD and Richard Johnson, MD||Our 25 research mentors are outstanding faculty at the University of Colorado Anschutz Medical Campus, representing many disciplines and departments. We look forward to continuing our tradition of excellence in training leaders in nephrology.||The position is within the T32 Training Program of the Division of Renal Diseases and Hypertension. The Nephrology training program, which has been funded for 48 consecutive years, seeks to continue to provide scientifically rigorous, multidisciplinary research training in academic nephrology to postdoctoral fellows who have previously earned M.D., and/or Ph.D. degrees. Individuals accepted into the training program dedicate two or more years to research activities in bench science, clinical nephrology research studies, and/or translational investigation. The program is enriched with regularly scheduled lectures and seminars as well as local, regional, and national courses. Participants have the option in enrolling in formal postgraduate course work at the University of Colorado Anschutz Medical Campus. The most important component of the proposed program is the intensive research training and/or translational investigation.||Betsy Pike, Renal Division Human Resources, email@example.com|
|08/05/2022||Sarah E. Clark, Assistant Professor||The Clark lab investigates host-pathogen interactions with a focus on innate immune responses to bacteria in the respiratory tract.||We are seeking a highly motivated Postdoctoral Fellow to spearhead research on how potentially beneficial members of the airway microbiome impact protection against lung infection with the bacterial pathogens Streptococcus pneumoniae and Haemophilus influenzae. Another active project investigates the host and microbial factors that promote bacterial otitis media (ear infection) using a newly developed murine model. Overall, the goal of these studies is to identify microbial factors and host immune pathways which improve the clearance and resolution of respiratory tract infections. The PI is committed to supporting the candidate’s career development and research progress, including the exploration of new project areas and collaborations. Individuals from diverse backgrounds are strongly encouraged to firstname.lastname@example.org|
|07/18/2022||Joshua Black||The Black lab studies how epigenetics regulate gene copy number and genomic instability. In particular, we are interested in how environmental stress causes epigenetic changes that target DNA rereplication of genes important for the stress response.||Projects in the lab will require some combination of chromatin state analysis using next generation sequencing approaches, DNA FISH, bioinformatics and data analysis, and molecular and cellular biology techniques. We utilize multiple model systems from yeast to mammalian cell culture best suited to address the particular question. Prior training in these areas is advantageous, however, successful candidates need not be proficient with all these tools when they apply. We are looking for candidates with interests in understanding the DNA rereplication response of metal stress, innate immune stress, epithelial to mesynchymal transition and how this goes awry in Down syndrome. Candidates interested in how DNA rereplication contributes to generation of extrachromosomal circular DNA (eccDNA) are also encouraged to email@example.com|
|04/13/2022||Cecilia Caino||The Caino lab studies the impact of organelle dynamics, key signaling pathways activated in metastatic cancer, and cancer metabolism in cancer progression. Visit external link for more information.||The Caino lab in the Department of Pharmacology has an opening for a full-time Postdoctoral Fellow to join our team Available projects include studies on the role of mitochondria shape, number and subcellular distribution in tumor cell invasion and metastatic dissemination (see Caino et al, PNAS 2015 Jul 14;112(28):8638-43; Caino et al, Nat Commun. 2016 Dec 19;7:13730). Alternatively, the postdoctoral fellow may work on understanding the role of the Intergrated Stress response (ISR) as a sensor of mitochondrial homeostasis and target for metastatic disease. See recent publications from our lab: Furnish et al, Mol Cancer Res. 2022 Jan 6. doi: 10.1158/1541-7786;Ghosh et al, PNAS. 2022 Feb 22;119(8):e2115624119). Research will involve biochemistry, molecular biology and cellular biology experimental procedures, high-throughput loss-of-function screenings and work with animal models of cancer and metastatic firstname.lastname@example.org|
|03/14/2022||Ross Kedl||Our primary focus is defining what drives strong CD8 T cell responses to vaccines||Some current projects with potential space for a new postdoc include: determining the unique metabolic state vaccine-elicited T cells (Tvac) adopt and how this might be exploited to enhance prophylactic or therapeutic (cancer) vaccine strategies; clarifying the transcription factor networks driving the development of memory Tvac and infection-elicited T cells (Tinf); a nearly completely dry-lab data analysis project comparing the transcriptomes of Tvac and Tinf during their priming, peak effector, and memory stages; and, defining the role(s) for B cells in promoting T cell responses to email@example.com|
|09/22/2021||Raphael Nemenoff, PhD||The Nemenoff laboratory is focused on examining molecular pathways that regulate the progression and metastasis of lung cancer.||This position reports directly to Dr. Raphael Nemenoff in the Division of Renal Diseases and Hypertension and is responsible for designing and conducting experiments to explore the role of the tumor microenvironment in mediating therapeutic response in preclinical models of non-small cell lung cancer(NSCLC). The project uses an orthotopic immunocompetent model of lung cancer to study mechanisms associated with response to both immunotherapy and targeted therapy. Our group has developed a panel of murine models and murine lung cancer cells comprising the major oncogenic drivers of human NSCLC. Proposed studies focus on the defining critical interactions that determine the depth and duration of response to specific therapeutic approaches.||Betsy Pike, Renal Division Human Resources, firstname.lastname@example.org|
|05/28/2021||Mary Weiser-Evans, PhD, FAHA||The Weiser-Evans laboratory uses fate-mapping genetic approaches combined with molecular analyses such as spatial transcriptomics, RNA-Seq, ChIP, and CyTOF mass cytometry to define mechanisms regulating cardiovascular disease progression.||In vivo mouse genetic approaches are complemented by in vitro studies. Human tissues are used to validate findings from pre-clinical studies in order to define the translational significance of our findings. Select projects include defining the role of PTEN promoter hypermethylation as a key regulator of cardiovascular disease progression as well as defining the mechanisms driving smooth muscle-to-stem cell reprogramming, determining the distinct functions of SMC-derived stem cells in the maintenance and repair of the vessel wall as well as their role in disease progression. Applicants should be highly motivated, detail-oriented, with excellent communication, writing, and organizational skills. Applicants must hold a Ph.D. or an equivalent degree in life sciences.||Betsy Pike, Renal Division Human Resources, email@example.com|