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07/16/2024 | Gita Alaghband | Postdoctoral research opportunity in the department of Computer Science Engineering at CU Denver. | We are seeking an individual with research experience and interest in implementing and evaluating deep reinforcement learning (DRL) systems to assist in developing explanation system to describe the decisions from such models. Minimum Qualifications: • Must be U.S. citizen and be able to commit time to support regular program meetings and milestones. Non-U.S. citizens cannot be considered due to requirements of the project funding. • A PhD in Computer Science or related field. • Experience in Artificial Intelligence/Machine Learning and have a strong programming background in Python. • Experience working on research projects in an academic setting or demonstration of high research potential. Salary: $4,707 per month. Please visit: external link for full job description and requirements to apply. Requisition number 34229. | Investigator: Professor Gita Alaghband (gita.alaghband@ucdenver.edu) | |
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06/26/2024 | Beth Warren, MD | Using an on-site motion capture space, including force plates, instrumented treadmill, and cameras, the HTC Biomechanics Laboratory aims to understand movement patterns that may lead to musculoskeletal bleeding in persons with bleeding disorders. | The Hemophilia and Thrombosis Center (HTC) Biomechanics Laboratory is seeking a postdoctoral research candidate to work on a project examining how bleeding in genetic bleeding disorders relates to movement patterns and modeled joint and muscle forces. The work is directed by Dr. Beth Warren (University of Colorado Anschutz Medical Campus, Department of Pediatrics) with co-mentorship by Dr. Brecca Gaffney (University of Colorado Anschutz Medical Campus, Departments of Mechanical Engineering and Bioengineering). This position is funded for 1 year. The salary structure is both attractive and nationally competitive. Other benefits include health/dental insurance, vacation/sick leave and access to all University facilities. The position is available immediately. Responsibilities will include modeling of joint and muscle forces using OpenSim from data collected from participants with and without bleeding disorders, and adapting models to investigate methods of injury prevention. | beth.warren@cuanschutz.edu, 303-724-0706 (work) | |
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05/23/2024 | Russ Glasgow | The position will help to integrate work across the Dissemination & Implementation Science Program (external link and the Colorado Program for Patient Centered Decisions (CPPCD) which are part of (ACCORDS). | The post doctoral position provides advanced training to health services researchers and clinicians and prepares fellows for positions in academic medicine. The postdoctoral fellow will collaborate on established projects, work as part of a team creating resources including interactive tools to support rapid and rigorous research, and be encouraged to conduct independent research with an emphasis on manuscript writing and grant submission. Responsibilities:Key Responsibilities needed: • Serve as a project lead to develop and execute a novel sub-project within the team’s research portfolio • Serve as the lead author of high quality manuscripts for submission to peer-reviewed scientific journals using lab or related data. • Assist general research operations in the group, which includes miscellaneous scientific, administrative, and educational activities. Please review attached document for full review of duties/qualifications/more information | Kate Noonan kate.noonan@cuansschutz.edu | |
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05/22/2024 | Lisa Spencer | Our studies are centered upon understanding the immunobiology of mucosal tissue eosinophils and defining mechanisms that underly their homeostatic and pathologic contributions to health and inflammatory diseases. | We are seeking a highly motivated individual(s) who thrives in a mentoring-rich, collaborative research environment. Active projects utilize primary human cells, patient samples, and mouse models to explore intestinal eosinophil functional phenotypes, bidirectional interfaces between tissue resident innate immune cells (primarily eosinophils, mast cells, and ILCs) and adaptive immunity, and systemic and local drivers of mucosal organ crosstalk in allergic inflammation. For additional information please see: www.spencerlab.org | lisa.spencer@cuanschutz.edu | |
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05/15/2024 | Elena Hsieh | The Hsieh Lab studies mechanistic and translational questions in human immunology, seeking a deeper understanding of normal immune function and the dysregulated processes that drive disease. | We are seeking a highly motivated immunologist to join our team. The Hsieh lab studies 1) “classic autoimmunity” (i.e., lupus) and 2) inborn errors of immunity (IEI) that present with autoimmunity/inflammation. Using primary human samples, in vitro cell lines, and CRISPR/Cas engineered mouse models of human disease, we identify and study novel IEI to dissect the molecular and cellular mechanisms that govern self-tolerance and anti-microbial immunity and provide critical insights for effective therapies in immunodeficiency, autoimmunity/inflammation, and malignancy. Visit external link for more information about our work. | elena.hsieh@cuanschutz.edu | |
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05/12/2024 | Heide Ford | Our laboratory focuses on the parallels between normal development and cancer, tumor cell plasticity, and metastasis. We focus on both transcriptional and translational mechanisms that induce plasticity as a means to enhance tumor progression. | The postdoc can work in various tumor types, including adult cancers such as breast cancer or glioblastoma, or various pediatric cancers such as rhabdomyosarcoma, Ewing Sarcoma, and medulloblastoma. In all contexts, we are interested in how either developmental transcription factors, or specialized mechanisms of mRNA translation, contribute to the ability of tumor cells to survive various stressors by enabling cellular plasticity. Our work is highly molecular in nature, and we utilize numerous cutting edge techniques such as RNA-seq, CUT&RUN, ATAC-Seq, Ribo-seq, amongst others. In addition, the work spans from biochemical/structural studies (in collaboration with others) to cell based and animal models (both zebrafish and mouse). | heide.ford@cuanschutz.edu | |
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05/12/2024 | Laurel Lenz | We study innate immunity and inflammation. We are defining mechanisms used by microbes and their products to regulate the production and effects of host cytokines and metabolism to tune innate immune cell activities. | We seek a fellow with strong experimental and analytical skills and a history of scientific productivity to contribute to our NIH funded studies that dissect cell biological and signaling mechanisms targeted by specific microbial products to modulate dendritic cells (DC) activity. Advanced techniques and methods will be employed in this work, including high resolution microscopy, biochemistry, molecular biology, genetics, and bioinformatics. The research involves use of established cell culture and co-culture models as well as in vivo (murine) infection models. | laurel.lenz@cuanschutz.edu | |
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05/09/2024 | Lori Sussel | The role of transcriptional regulation and RNA processing in regulating pancreatic islet cell function using mouse models and human embryonic stem cells. | We are seeking highly motivated individuals who have recently completed their graduate studies. Prospective postdocs should have an interest in pursuing islet biology and diabetes disease mechanisms, with expertise in molecular biology and experience with either mouse models or human stem cell biology. Fellows will be expected to work independently to generate data towards their own fellowship applications and publications. Quality mentorship and career guidance will be provided to groom fellows for a career in academic research. | lori.sussel@cuanschutz.edu | |
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05/07/2024 | Kurt Stenmark, Professor and Director of The Cardiovascular and Pulmonary Research Program | The Cardiovascular and Pulmonary Research Program focuses on pioneering Pulmonary Hypertension (PH) research. | The project is based on the hypothesis that activation of the complement system—a critical component of the innate immune response—plays a pivotal role in the initiation and progression of PH. This systemic activation results in local inflammation and vascular remodeling, characteristics that are central to the pathogenesis of PH. The research aims to dissect the molecular mechanisms by which the complement system influences these pathological changes and to explore targeted therapeutic strategies that could mitigate these effects. The work utilizes many mouse, rat, and large animal models to investigate various etiologies of PH. Collaborative Environment: The postdoc will work within a multidisciplinary team comprising experts in pulmonary vascular biology, complement biology, immunology, and proteomics. This collaborative setting is designed to foster innovative approaches and rapid translation of research findings from bench to bedside. | andy.poczobutt@cuanschutz.edu | |
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05/07/2024 | Chandra Tucker, Professor | Synthetic cell biology | Open to prospective postdoctoral inquiries. We are seek talented researchers interested in the intersection of cell biology, optogenetic and chemical genetic tools, and cell quality control during cell health and disease, including aging and neurodegenerative disease. We are studying how cells maintain functional protein assemblies such as biomolecular condensates while preventing aggregation of protein components, how to therapeutically ameliorate dysfunctional protein assemblies related to disease states, and how to utilize protein assemblies for synthetic biology applications. For more information, please see: www.tucker-lab.org | chandra.tucker@cuanschutz.edu | |
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05/07/2024 | Julia Dunn | The Dunn Lab focuses on eosinophil biology within the context of mucosal tissues, particularly as this relates to the onset and resolution of allergic inflammation. Learn more at dunnimmunolab.com | The Dunn lab is currently accepting applications for postdoctoral research fellows. We are a translational immunology lab, using ex vivo tissue culture and organoid systems, in vivo murine models, and primary human tissues to understand the causes and consequences of eosinophil specialization within mucosal sites. Ideal candidates will have a foundational background in immunology and practical experience in two or more of the following: mammalian tissue culture, mouse handling, flow cytometry, immunofluorescence, bioinformatics and next-gen sequencing. The successful applicant will be expected to produce and analyze high quality data, prepare manuscripts, collaborate with members of the Dunn lab as well as neighboring labs within the Gastrointestinal Eosinophilic Diseases Program (GEDP) and Mucosal Immunology Program (MIP), and will receive support to attend one conference, annually. | julia.2.dunn@cuanschutz.edu | |
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05/07/2024 | Kristyn Masters, Professor and Chair of Bioengineering | The Masters Lab uses tissue engineering to create in vitro environments that model disease progression. We have a particular interest in cardiovascular diseases and sex differences, but are interested in branching out to new systems. | Current project funding supports the creation of tissue-engineered models of both aging and disease, with a specific focus on cardiovascular diseases. Experience with biomaterials, hydrogels, and/or the extracellular matrix is a plus! Key Responsibilities: • Develop innovative approaches to designing in vitro tissue-mimicking platforms and apply these platforms to advance our understanding of aging and disease pathogenesis. • Design and lead tissue engineering research projects, analyze data, and interpret results. • Prepare and publish manuscripts in scientific journals and present at conferences. • Mentor and train other group members, such as graduate and undergraduate students. • Pursue computational, experimental, and clinical collaborations. • Develop and progress the candidate’s career goals. For additional details see: external link | Kristyn Masters, kristyn.masters@cuanschutz.edu | |
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05/07/2024 | Joanna Arch | The Arch lab focuses on understanding and developing interventions for anxiety disorders, stress, and coping with cancer. We study mindfulness and acceptance-based as well as exposure-based behavioral interventions. | We are seeking a postdoctoral fellow with strong data management and analytic skills to join our multidisciplinary team of experts in clinical/health psychology, oncology, palliative care, social work, and biostatistics. This role involves work on two NIH R01-funded randomized clinical trials of Acceptance and Commitment Therapy (ACT) telehealth interventions for anxiety, depression, fatigue, and health adherence behaviors among adults with cancer. Opportunities abound to train, deliver, and supervise ACT interventions; publish; present; and mentor graduate and undergraduate students. For application and additional details see: jobs.colorado.edu/jobs/JobDetail/?jobId=55828 | joanna.arch@colorado.edu | |
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05/07/2024 | Allie McClure (Biochemistry and Molecular Genetics) | Our lab seeks to understand the relationship between DNA replication and the cell cycle: the last regions of the genome to be replicated can be synthesized during mitosis, in a process that cancer cells rely on heavily. (see mcclurelabdna.org) | We have two projects in the lab that a postdoc could work on: 1) Using long-read sequencing to identify when, where, and in what circumstances particular "sensitive" regions of the genome are replicated in mitosis. Background in molecular biology is required, and experience with long-read sequencing would be preferred. 2) Using protein biochemistry to identify the molecular targets of mitotic proteins including helicases and nucleases during mitotic DNA replication. Background in molecular biology required, experience with protein purification preferred. Postdocs in the lab work with Allie to submit postdoc fellowships and develop skills important for their career of choice including mentoring, teaching, and scientific project development. Postdocs are also expected to contribute to overall positive lab culture. | allison.mcclure@cuanschutz.edu | |
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05/07/2024 | Antonio R. Porras, PhD | Our team develops medical image computing and artificial intelligence methods, together with software tools for their clinical translation, to better understand, identify and treatment medical conditions. | The new postdoctoral researcher will be responsible for the design and development of novel medical image computing and machine/deep learning methods. Their scope may include image segmentation, image registration, disease screening and diagnosis, discovery of new image-based biomarkers, quantitative image-based phenotyping, anatomical modeling and/or predictive analysis. In addition, the selected candidate will collaborate with other faculty, students and physicians in the clinical translation of the developed methods. | antonio.porras@cuanschutz.edu | |
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05/06/2024 | Darleen Sandoval | The Sandoval lab uses genetic mouse models and in vivo physiological approaches to study the role of the gut-brain axis in regulating metabolism. | 2023 was a break-through year for obesity treatment. In addition to bariatric surgery, we now have obesity multiple drugs that are reaching the efficacy of bariatric surgery and multiple more promising drugs in the pipeline. Like bariatric surgery, these drugs target the gut-brain axis. The Sandoval lab uses genetic mouse models, chemogenetic and in vivo physiological strategies to study the role of the gut-brain axis in regulating body weight, feeding, and metabolism. Dr. Sandoval and the postdoctoral candidate will work together to develop an individualized training plan aimed at advancement of the candidates technical and professional skillsets in order for the candidate to achieve their professional career goals whether that is to obtain a position in the academic or industry settings. Our research requires a team approach, and we are looking for someone who is interested in being a part of a diverse and productive team. external link | darleen.sandoval@cuanschutz.edu | |
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05/06/2024 | Charles Sagerstrom | Transcriptional and epigenetic control of cell fate decisions during embryonic development | During embryogenesis, the developing embryo goes through numerous transitions as new tissues, organs and cell types are formed. Each such transition is driven by a change in gene expression that can go awry and cause birth defects. We are interested in understanding how transcription factors and chromatin regulators drive gene expression programs to support the formation of new cells and tissues, using zebrafish as a model. Our group is looking for postdoctoral fellows to join our work using bioinformatics, imaging and genetic/genomic tools (scRNAseq, scATACseq, CRISPR, transgenesis) to unravel the control of cell fate decisions. Lab website: external link . Recent manuscript: doi.org/10.7554/eLife.87772.. | Charles.sagerstrom@cuanschutz.edu | |
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05/03/2024 | Christian Mosimann | The Mosimann lab studies the molecular mechanisms of cell fate determination during development and disease. | To expand our team in the Section of Developmental Biology, Dept of Pediatrics, we are open to inquiries from those with a background in molecular biology, development, gene regulation, or related topics. We study the molecular mechanisms of cell fate determination during development and disease. As main paradigm, we study the development and patterning of the lateral plate mesoderm (LPM), the joint origin of the cardiovascular, blood, kidney, and limb lineages. We apply advanced transgenics, enhancer discovery, lineage tracing, cross-species comparisons, and live imaging using the zebrafish as principal model. Of special interest are genetic causes of congenital cardiovascular and spine diseases. Our work provides an interface to development, evo-devo, and disease modeling projects that involve a national, and international collaborators. While our postdoc positions are funded, we actively support fellowship applications including F32, K99, and more to foster careers and independen | christian.mosimann@cuanschutz.edu | |
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05/03/2024 | Richard Benninger | The Benninger lab broadly investigates the physiological mechanisms underlying the regulation of the endocrine pancreas how dysregulation drives diabetes. This includes remodeling of the microvasculature and blood flow regulation | The ideal candidate will develop projects related to applying ultrasound imaging and other physiological approaches to understand the mechanisms underlying islet microvasculature dysfunction and blood flow changes in type1 diabetes. This can also include applying advanced signal processing approaches for high resolution imaging, developing computational models of islet blood flow changes; characterizing and applying novel ultrasound contrast agents including molecular targeted agents; and use of contrast-enhanced ultrasound in ongoing clinical studies. The candidate will also have resources and mentoring to develop their own research interests and to develop new research skills. The candidate can also optionally mentor junior scientists, give guest lectures and receive guidance in writing fellowship applications. They must be highly motivated and willing to learn new techniques and approaches, and able to work in an interdisciplinary team | Further details of the Benninger lab can be found at benningerlab.com Contact richard.benninger@cuanschutz.edu for questions | |
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05/02/2024 | S. Christopher Derderian | The Derderian lab studies the role of microRNAs in regulating the pathogenesis of fetal growth restriction. | Postdoc research position available for an individual interested in fetal and placental biology. Experience with transcriptomics is desirable. We focus on molecular signals dysregulated in impaired placentation and utilize animal, culture, and organoid models of fetal growth restriction. Future interests of my lab include in utero single base pair editing. The goal of this position would be the generation of preliminary data to put towards the development of their own federal and/or private foundation grant application. Postdocs would also be expected to mentor clinical trainees (often general surgery residents) in the lab who are less familiar with basic science research. | s.derderian@cuanschutz.edu | |
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05/01/2024 | Developmental Psychobiology Research Group (DPRG) | Developmental Psychobiology Research Group (DPRG) T32 postdoctoral training program (T32MH015442) | A two-year training program is offered, which includes a Core Curriculum to be completed by all trainees, seminar participation, and individual research in one or more faculty laboratories. Research training organizes around the identification, causes, natural progression, and treatment of developmental psychopathology. A particular emphasis of training is the development of multispecialty collaborations allowing for synergistic basic and clinical approaches to research. Training options are available in basic and molecular, biomarkers, genetics, neuroimaging, epidemiology, phenomenology, treatment, and intervention sciences for a variety of developmental psychiatric disorders including ADHD, aggression, conduct disorder, anxiety, autism, bipolar, depression, schizophrenia, and substance use disorder. Training for transition to research independence, including manuscript preparation and grant submission, are an emphasis of this program | DPRG@ucdenver.edu | |
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05/01/2024 | Rebecca Schweppe, PhD, Professor of Medicine | The focus of my lab is to define the role of key signal transduction mechanisms that regulate thyroid cancer growth and metastasis in order to develop new therapeutic strategies. | The goals of this fellowship are to define the mechanisms by which deregulated kinase signaling in the MAPK, Src, and FAK pathways promote thyroid tumorigenesis. Project #1 focuses on our discovery showing FAK accumulates in the nucleolus to promote ribosome biogenesis to drive thyroid growth and survival. The goals of this project are to determine the mechanisms by which FAK promotes ribosome biogenesis and how to target this novel function in vivo. Project #2 focuses on the mechanisms by which transcriptional reprogramming promotes resistance to BRAF inhibition. These projects will use unbiased approaches (proteomics/transcriptomics) and focused in vitro approaches (Westerns, growth/apoptosis assays, microscopy, invasion/migration assays), along with innovative in vivo models.Together, these tools and approaches will lead to a better understanding of kinase signaling in thyroid cancer and develop durable strategies for targeting the most aggressive forms of the disease. | Rebecca.Schweppe@cuanschutz.edu | |
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04/30/2024 | Aaron Michels, Professor of Medicine, Pediatrics, and Immunology | The Michels' laboratory (michelslab.com) performs cutting-edge immunology research into the pathogenesis, prediction, and prevention of type 1 diabetes (childhood onset diabetes) and has been continuously funded by the NIH for more than a decade. | We are seeking a motivated full-time post-doctoral fellow to conduct research into the immune-mediated mechanisms by which specific HLA class II molecules provide protection and confer susceptibility in type 1 diabetes. Mouse models and well-characterized human samples will be used to investigate antigen-specific T cell function and T cell receptor repertoires to self-peptide/HLA complexes. The duties include performing ‘wet’ laboratory techniques, bioinformatic data analysis, and manuscript/grant writing. | aaron.michels@cuanschutz.edu | |
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04/29/2024 | Joshua Gowin | The Brain Alcohol Research laboratory focuses on using brain imaging to understand risk for substance use disorders and to understand the process of recovery. | We are seeking a post doc to study brain function as it relates to substance use. The position involves analyzing brain imaging scans (fMRI), including task and resting state analysis. Fellows will generate data toward publishing papers and toward federally funded fellowship applications. | joshua.gowin@cuanschutz.edu | |
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04/23/2024 | Stephanie Wesolowski | Fetal metabolic physiology and developmental programming | Current studies in our research program are focused on understanding the mechanisms for the early activation of fetal hepatic glucose production and development of hepatic insulin resistance, specifically the role of reduced glucose versus oxygen supply to the fetus, both key features of placental insufficiency and resulting fetal growth restriction (FGR). This is important in understanding why FGR offspring have increased susceptibility to diabetes across their lifespan. We also have projects investigating the effects of maternal high fat diet and obesity on offspring metabolism, specifically the early development of hepatocellular injury, including fibrosis and steatosis, and immune cell reprogramming. | Stephanie.wesolowski@cuanschutz.edu | |
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04/23/2024 | Mark Dell'Acqua | The Dell'Acqua lab studies receptor and ion channel signaling complexes regulating neuronal plasticity underlying normal learning and memory as well as cognitive dysfunction associated with neurodevelopmental and neurodegenerative diseases. | Open to postdoc inquiries. Applicants should have a PhD in neuroscience, pharmacology, cell biology, biochemistry or a related field. Prior experience in electrophysiology and/or fluorescence imaging is a plus but not required. Solid publication record is desired, with good written and verbal communication skills in English. Ongoing research projects focus on characterizing the role of postsynaptic scaffold proteins, kinases and phosphatases in regulating glutamate receptors, GABA receptors, and voltage-gated Ca+ channels during synaptic plasticity. Additional projects focus on how neuronal excitation is coupled to transcription to control gene expression. We are studying the function of these molecular and cellular mechanisms during normal synaptic plasticity as well as how dysfunction in these pathways contributes to nervous system disorders, including autism, intellectual disability, Alzheimer's disease, and vascular dementia. | mark.dellacqua@cuanschutz.edu | |
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01/11/2023 | Nancy F. Krebs | Nutrition – NIH T32 Research Fellowship T32DK007658-33 | Individuals who have completed residency training, PhD or other terminal degree may apply for a research fellowship in nutrition. The objective of this program is to provide research training in the nutritional sciences to physician scientists, basic researchers, and behavioral scientists who are committed to prevention of disease and health promotion through careers in human nutrition. Nutrition Training Faculty provide the foundation of nutrition research. Areas of interest include obesity and energy balance; behavioral research related to eating & obesity; health promotion & nutrition education; implementation science; molecular, genetic, and environmental basis of insulin resistance and Type 2 diabetes; micronutrient homeostasis and effects of nutrient deficiency states; global nutrition; maternal and fetal nutrient utilization; fetal origins of adult disease, human aging; and the epidemiology of nutrition-related conditions | carolyn.doyle@cuanschutz.edu 303-724-5850 |